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Document ID (ISN)48792
CIS number 87-1433
ISBN(s) 91-7464-221-9
Year 1984
Convention or series no. Arbete och Hälsa 1984:28
Title Nordic Expert Group for Documentation of Occupational Exposure Limits - 50. Benomyl
Original title Nordiska expertgruppen för gränsvärdesdokumentation - 50. Benomyl [in Swedish]
Bibliographic information Arbetarskyddsstyrelsen, Publikationsservice, 171 84 Solna, Sweden, 1984. 42p. 55 ref.
Abstract The metabolism and toxic effects of benomyl and its analogues carbendazim and thiophanate-methyl are reviewed. The acute toxicity of benomyl is very low in rodents. Acute toxic effects at low concentrations are only found in aquatic organisms. Long-term toxicity studies indicate that testes and spermatogenesis are special targets of the toxic manifestations of benomyl and its degradation product carbendazim. Benomyl also causes mitotic disturbances. Chromosome damage and point mutations have been caused by benomyl. Benomyl at moderate dose levels has caused malformations and foetal deaths in mouse and rat. Evidence exists suggesting hepatocarcinogenicity for benomyl and carbendazim in mice. Benomyl must be considered a potential mutagen, carcinogen and teratogen. The possible effects on health of benomyl are most obviously shared by carbendazim and thiophanate-methyl (metabolised into carbendazim). Quantitative estimation of the risk to man, especially in occupational exposure to benomyl, is impossible at present due to a lack of human data.
Descriptors (primary) threshold limit values; benomyl; genetic effects; fungicides; determination of exposure limits; toxicology
Descriptors (secondary) mutagenic effects; toxic effects; literature survey; Nordic Countries; metabolic process; methyl 2-benzimidazolylcarbamate; criteria document; liver cancer; animal experiments; chromosome changes; teratogenic effects; TLV list; carcinogenic effects; thophanate-methyl
Document type F - Information notes, codes of practice, standards
Subject(s) Agriculture, fishing, animal husbandry
Broad subject area(s) Chemical safety
Browse category(ies) Antifertility and prenatal effects
Occupational exposure limits
Amides
Agricultural chemicals
Genetic factors in reaction to exposures