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Document ID (ISN)48514
CIS number 87-1340
ISSN - Serial title 0002-8894 - American Industrial Hygiene Association Journal
Year 1987
Convention or series no.
Author(s) Tikuisis P., Madill H.D., Gill B.J., Lewis W.F., Cox K.M., Kane D.M.
Title A critical analysis of the use of the CFK equation in predicting COHb formation
Bibliographic information Mar. 1987, Vol.48, No.3, p.208-213. Illus. 14 ref.
Abstract Fifteen healthy young males, nine at rest and six at exercise, were exposed to high transient levels of carbon monoxide (CO) to simulate the breathing environment measured in an armoured vehicle during weapons firing. Depending on the dosage, the CO exposures raised the subjects' carboxyhaemoglobin saturation (%COHb) from 1.7% to 17.3%. The measured % COHb levels compared favourably (regression coefficient b=1.04) with those predicted by the theoretical model of Coburn et al. When the same model was applied to a method proposed by NIOSH, however, a significant overprediction was found (b=1.28). It appears that this overprediction results primarily from the failure to take into account the presence of water vapour in the lungs when the inspired pressure of CO is considered, and from the use of incorrect values for alveolar ventilation. These results demonstrate the errors that may arise from the incorrect utilisation of the equation by Coburn et al. and the effect that this may have upon the calculation of the limits for safe occupational exposure to CO.
Descriptors (primary) carbon monoxide; prediction formulae; carboxyhaemoglobin level
Descriptors (secondary) human experiments; limitation of exposure
Document type D - Periodical articles
Subject(s) Toxic and dangerous substances
Broad subject area(s) Chemical safety
Browse category(ies) Blood diseases
Carbon monoxide
Inorganic substances