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Document ID (ISN)48426
CIS number 87-1335
ISSN - Serial title 0002-8894 - American Industrial Hygiene Association Journal
Year 1987
Convention or series no.
Author(s) Saltzman B.E.
Title Lognormal model for health risk assessment of fluctuating concentrations
Bibliographic information Feb. 1987, Vol.48, No.2, p.140-149. Illus. 27 ref.
Abstract Health risk assessments of exposures to harmful materials increasingly are required because of legal and economic pressures. An important part of the procedure is the mathematical model for the dose-effects relation. If a linear no-threshold relation is assumed, then the mean of fluctuating concentrations may be used for the calculation of health risk. For threshold and nonlinear relations the calculation with the use of the mean concentration is inaccurate because higher concentrations produce disproportionately higher effects. A mathematical model based upon lognormal concentrations and probit effects is proposed. Rather than monitoring concentrations for unlikely high values, the method requires estimation of their geometric mean and geometric standard deviation. A health risk assessment may then be calculated simply and conveniently from the charts and tables provided. The method clarifies some issues and the specifics of utilising and improving the required data.
Descriptors (primary) toxic substances; mathematical models; hazard evaluation
Descriptors (secondary) dose-response relationship
Document type D - Periodical articles
Subject(s) Toxic and dangerous substances
Broad subject area(s) Chemical safety
Browse category(ies) Risk evaluation