|Document ID (ISN)||48215|
|ISSN - Serial title
||0340-0131 - International Archives of Occupational and Environmental Health
|Convention or series no.
||Wysocki J., Kalina Z., Owczarzy I.
||Effect of organophosphoric pesticides on the behaviour of NBT-dye reduction and E rosette formation tests in human blood
||1987, Vol.59, No.1, p.63-71. 18 ref.
||These investigations revealed a significant decrease in the values of the examined cellular parameters of human immunity and in the absolute lymphocyte count in peripheral blood in 31 workers, as compared to 30 controls. Moreover, the NBT-dye reduction decrease was correlated with a reduced acetylcholinesterase (AChE) activity. The exposure time showed a negative linear correlation with the phagocytic index of the NBT-dye reduction test. It is concluded that depressed NBT-dye reduction and diminished spontaneous E rosette formation may be regarded as a reflection of the effect of organophosphoric chemicals on metabolic and membrane damage of human cells. A possible role of endogenous acetylcholine poisoning in the development of these pathologic conditions is also discussed.
||organophosphorus compounds; serological reactions; haematological changes; pesticides
||acetylcholinesterase; blood cytology; hyperglycaemia; fragility of blood cells
||D - Periodical articles
||Agriculture, fishing, animal husbandry
|Broad subject area(s)
||Occupational medicine, epidemiology