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CISDOC database

Document ID (ISN)48215
CIS number 87-927
ISSN - Serial title 0340-0131 - International Archives of Occupational and Environmental Health
Year 1987
Convention or series no.
Author(s) Wysocki J., Kalina Z., Owczarzy I.
Title Effect of organophosphoric pesticides on the behaviour of NBT-dye reduction and E rosette formation tests in human blood
Bibliographic information 1987, Vol.59, No.1, p.63-71. 18 ref.
Abstract These investigations revealed a significant decrease in the values of the examined cellular parameters of human immunity and in the absolute lymphocyte count in peripheral blood in 31 workers, as compared to 30 controls. Moreover, the NBT-dye reduction decrease was correlated with a reduced acetylcholinesterase (AChE) activity. The exposure time showed a negative linear correlation with the phagocytic index of the NBT-dye reduction test. It is concluded that depressed NBT-dye reduction and diminished spontaneous E rosette formation may be regarded as a reflection of the effect of organophosphoric chemicals on metabolic and membrane damage of human cells. A possible role of endogenous acetylcholine poisoning in the development of these pathologic conditions is also discussed.
Descriptors (primary) organophosphorus compounds; serological reactions; haematological changes; pesticides
Descriptors (secondary) acetylcholinesterase; blood cytology; hyperglycaemia; fragility of blood cells
Document type D - Periodical articles
Subject(s) Agriculture, fishing, animal husbandry
Broad subject area(s) Occupational medicine, epidemiology
Browse category(ies) Blood diseases
Agricultural chemicals