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CISDOC database

Document ID (ISN)47846
CIS number 87-616
ISSN - Serial title 0340-0131 - International Archives of Occupational and Environmental Health
Year 1986
Convention or series no.
Author(s) Mohtashamipur E., Norpoth K., Hallerberg B.
Title A fraction of beech wood mutagenic in the Salmonella/mammalian microsome assay
Bibliographic information 1986, Vol.58, No.3, p.227-234. 34 ref.
Abstract Base-pair substitition mutagens were isolated from the dusts of several untreated samples of beech wood and tested for mutagenicity in the Salmonella/mammalian microsome assay. These compounds reverted Salmonella typhimurium his-TA100 in the presence of Aroclor-induced rat S9 liver extract. These mutagens were toxic to the cells when tested in a histidine-rich medium (complete medium). Mutagenicity of the non-fractionated wood-dust extracts could not be confirmed due to the presence of some inhibitory compounds. These inhibitors counteracted the reversion of bacteria when known mutagens, such as benzo(a)pyrene, aflatoxin B1 and ethyl methanesulfonate, were tested. The results indicate that beech wood-dust contains (a) mutagenic constituent(s) which may contribute to nasal cancer among woodworkers, especially in the furniture industry.
Descriptors (primary) mutagenic effects; wood; furniture industry; sawdust; woodworking industry; nasal cancer
Descriptors (secondary) mutagenicity tests; in vitro experiments
Document type D - Periodical articles
Subject(s) Woodworking industry
Broad subject area(s) Chemical safety
Browse category(ies) Antifertility and prenatal effects
Diseases of the respiratory system (except for pneumoconiosis & similar)
Woodworking industry
Lumber and the woodworking industry
Genetic factors in reaction to exposures