Document ID (ISN) | 47791 |
CIS number |
87-589 |
ISSN - Serial title |
Journal of the Kumamoto Medical Society |
Year |
1986 |
Convention or series no. |
|
Author(s) |
Nomura Y., Nojiri A., Kudo S., Hotta N. |
Title |
Two cases of transitional cell carcinoma of urinary tract in patients with chronic arsenic poisoning |
Original title |
Mansei hiso-chūdokushō kanja ni hassei shita nyōro akusei-shuyō [in Japanese] |
Bibliographic information |
Mar. 1986, Vol.60, No.1, p.13-24. Illus. 36 ref. |
Abstract |
Malignant neoplasm of the urinary tract was observed in 2 patients with chronic arsenic poisoning in Toroku district, Miyazaki Prefecture, Japan, where arsenious acid had been produced from 1920 to 1962. Each patient had a history of environmental and occupational exposure to arsenic for a long period and presented clinical manifestations of chronic arsenic poisoning. A 67-year old woman developed a skin lesion of Bowen's disease in the left scapular part and a bladder tumour, respectively 53 years and 57 years after her first exposure to arsenic. A 55-year old man developed Bowen's disease in the left lower abdomen and tumour in the left ureter, respectively 53 years and 54 years after his first exposure. In both cases surgical treatment was performed. However, excision of the tumours was impossible because of tight adhesion and infiltration into the surrounding tissues. A histological examination of the biopsy specimens of the tumours revealed transitional cell carcinoma with squamous cell metaplasia and a high degree of malignancy in each case. Some recent epidemiological data on arsenic-related cancer support the conclusion that the four malignant epitheliomas observed in these cases are due to late effects of chronic arsenic poisoning. |
Descriptors (primary) |
genito-urinary system diseases; neoplasms; arsenic trioxide; arsenic and compounds |
Descriptors (secondary) |
Japan; chronic poisoning; skin diseases; case study |
Document type |
D - Periodical articles |
Subject(s) |
Occupational pathology
|
Broad subject area(s) |
Chemical safety
|
Browse category(ies) |
Arsenic and compounds Inorganic substances
|