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Document ID (ISN)47791
CIS number 87-589
ISSN - Serial title Journal of the Kumamoto Medical Society
Year 1986
Convention or series no.
Author(s) Nomura Y., Nojiri A., Kudo S., Hotta N.
Title Two cases of transitional cell carcinoma of urinary tract in patients with chronic arsenic poisoning
Original title Mansei hiso-chūdokushō kanja ni hassei shita nyōro akusei-shuyō [in Japanese]
Bibliographic information Mar. 1986, Vol.60, No.1, p.13-24. Illus. 36 ref.
Abstract Malignant neoplasm of the urinary tract was observed in 2 patients with chronic arsenic poisoning in Toroku district, Miyazaki Prefecture, Japan, where arsenious acid had been produced from 1920 to 1962. Each patient had a history of environmental and occupational exposure to arsenic for a long period and presented clinical manifestations of chronic arsenic poisoning. A 67-year old woman developed a skin lesion of Bowen's disease in the left scapular part and a bladder tumour, respectively 53 years and 57 years after her first exposure to arsenic. A 55-year old man developed Bowen's disease in the left lower abdomen and tumour in the left ureter, respectively 53 years and 54 years after his first exposure. In both cases surgical treatment was performed. However, excision of the tumours was impossible because of tight adhesion and infiltration into the surrounding tissues. A histological examination of the biopsy specimens of the tumours revealed transitional cell carcinoma with squamous cell metaplasia and a high degree of malignancy in each case. Some recent epidemiological data on arsenic-related cancer support the conclusion that the four malignant epitheliomas observed in these cases are due to late effects of chronic arsenic poisoning.
Descriptors (primary) genito-urinary system diseases; neoplasms; arsenic trioxide; arsenic and compounds
Descriptors (secondary) Japan; chronic poisoning; skin diseases; case study
Document type D - Periodical articles
Subject(s) Occupational pathology
Broad subject area(s) Chemical safety
Browse category(ies) Arsenic and compounds
Inorganic substances