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CISDOC database

Document ID (ISN)47722
CIS number 87-558
ISSN - Serial title 0340-0131 - International Archives of Occupational and Environmental Health
Year 1986
Convention or series no.
Author(s) Mazur G., Baur X., Pfaller A., R÷mmelt H.
Title Determination of toluene diisocyanate in air by HPLC and band-tape monitors
Bibliographic information 1986, Vol.58, No.4, p.269-276. Illus. 19 ref.
Abstract An improved high-pressure liquid chromatographic (HPLC) method was developed for determining the atmospheric concentration of toluene diisocyanate (TDI). 1-(2-pyridyl)-piperazine in toluene was used as reagent absorber solution. Reversed-phase chromatography was used with a simple efficient buffer system (0.1% aqueous trifluoroacetic acid-acetonitrile, 85:15%) in an isocratic elution mode. The TDI levels obtained with 2 identical continuous monitors were checked by using the values from HPLC as reference. Under identical experimental conditions the 2 monitors gave readings varying by >100%. At low humidity the monitor values were considerably lower than the HPLC values. At an absolute humidity of 11.7gH2O/m3 (58% relative humidity) the values of one of the monitors agreed with those from HPLC. The values obtained with these devices in the continuous monitoring of TDI concentration in places of work, or epidemiological studies, should be assessed with caution. HPLC offers a useful reference method for monitoring the accuracy of such devices.
Descriptors (primary) tolylene diisocyanate; exposure evaluation; high-pressure liquid chromatography; continuous monitoring; determination in air
Descriptors (secondary) isocyanates; 2,6-tolylene diisocyanate; comparative study; chromatography; colorimetry; 2,4-tolylene diisocyanate
Document type D - Periodical articles
Subject(s) Toxic and dangerous substances
Broad subject area(s) Chemical safety
Browse category(ies) Exposure evaluation
Cyano compounds