ILO Home
Go to the home page
Site map | Contact us Franšais | Espa˝ol

CISDOC database

Document ID (ISN)47299
CIS number 86-1996
ISSN - Serial title 0096-1736 - Journal of Occupational Medicine
Year 1986
Convention or series no.
Author(s) Carrano A.V.
Title Chromosomal alterations as markers of exposure and effect
Bibliographic information Oct. 1986, Vol.28, No.10, p.1112-1116. Illus. 28 ref.
Abstract Structural changes in chromosomes were one of the first recognised forms of genetic injury resulting from exposure to physical and chemical agents. Depending on the lesions induced in the DNA, and therefore, on the nature of the genotoxic substances, damage to chromosomes falls into 2 categories, structural aberrations and sister chromatid exchange (SCE). Because these 2 end points respond differently to chromatin lesions, they are complementary in any study designed to identify potential exposure. The circulating lymphocyte in the human is an appropriate cell type in which to measure cytogenetic changes because it is readily accessible, carries genotoxic substances and their metabolites throughout the body, is long-lived, and can integrate exposure. In animal and human studies, it has been shown that both SCEs and aberrations can persist in the lymphocyte following acute or chronic exposure.
Descriptors (primary) early diagnosis; medical supervision; chromosome changes; exposure evaluation
Descriptors (secondary) biological and medical tests
Document type D - Periodical articles
Subject(s) Occupational pathology
Broad subject area(s)
Browse category(ies) Antifertility and prenatal effects
Genetic factors in reaction to exposures
Exposure evaluation