| Document ID (ISN) | 46983 |
| CIS number |
86-1646 |
| ISSN - Serial title |
0387-821X - Journal of UOEH |
| Year |
1985 |
| Convention or series no. |
|
| Author(s) |
Koga M., Hori H., Tanaka I., Akiyama T., Inoue N. |
| Title |
Quantitative analysis of urinary ethylene glycol in rats |
| Bibliographic information |
Mar. 1985, Vol.7, No.1, p.45-49. Illus. 7 ref. |
| Abstract |
Ethylene glycol in urine was separated by azeotropic distillation and esterified with n-butylboronic acid. The derivatised ethylene glycol was separated by gaz chromatography at 70° on a 2m by 3mm glass column of 2% OV-225 on 60-80 mesh Uniport HPS. A flame ionisation detector was used. Known amounts of z-methylcyclohexanone were included in the samples as internal standards. A linear calibration curve was obtained up to 500µg/mL of ethylene glycol. The detection limit was 10µg/mL and the relative standard deviation was 3.5% for 100µg/mL of ethylene glycol. This method was used to determine the urinary excretion of ethylene glycol in rats exposed to ethylene oxide at various concentrations (50-500ppm). The amounts of ethylene glycol excreted were sigmoidally dependent on the concentration of ethylene oxide to which the rats had been exposed. |
| Descriptors (primary) |
ethylene glycol; ethylene oxide; gas-liquid chromatography; determination in urine; exposure evaluation |
| Descriptors (secondary) |
description of technique; animal experiments |
| Document type |
D - Periodical articles |
| Subject(s) |
Toxic and dangerous substances
|
| Broad subject area(s) |
Occupational medicine, epidemiology
|
| Browse category(ies) |
Alcohols
Ethylene oxide
Exposure evaluation
Glycols
Ethers
|
