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CISDOC database

Document ID (ISN)46945
CIS number 86-1700
ISSN - Serial title 0304-3894 - Journal of Hazardous Materials
Year 1986
Convention or series no.
Author(s) Ammann H.M.
Title A new look at physiologic respiratory response to H2S poisoning
Bibliographic information Aug. 1986, Vol.13, No.3, p.369-374. Illus. 17 ref.
Abstract Ever since the role of the carotid bodies in controlling ventilation was elucidated by Heymans in 1932, researchers have puzzled over the seeming paradox presented by the action of hydrogen sulfide gas on the nervous system. The dominant effect is depression of function, but the neural receptors of the carotids appear to be stimulated, resulting in hyperpnoea at sublethal exposures. This effect is examined in the light of the known cellular mechanisms of poisoning by H2S, which inhibits the enzyme cytochrome oxidase, stopping oxidative metabolism. The argument is made that H2S affects the carotid sensors in the same manner as reduced oxygen tension, thus resulting in increased rate and depth of ventilation.
Descriptors (primary) hydrogen sulfide; respiratory impairment; inhalation toxicity; neurological effects
Descriptors (secondary)
Document type D - Periodical articles
Subject(s) Occupational pathology
Broad subject area(s) Occupational medicine, epidemiology
Browse category(ies) Diseases of the nervous system
Inorganic sulfur compounds
Inorganic substances
Diseases of the respiratory system (except for pneumoconiosis & similar)