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Document ID (ISN)46621
CIS number 86-1350
ISSN - Serial title 0002-8894 - American Industrial Hygiene Association Journal
Year 1986
Convention or series no.
Author(s) Sargent E.V., Kirk G.D., Hite M.
Title Hazard evaluation of monochloroacetone
Bibliographic information July 1986, Vol.47, No.7, p.375-378. 9 ref.
Abstract This compound was introduced in 1914 as a war gas, and is presently used as a chemical intermediate in various industrial processes. Risk assessment indicates that monochloroacetone is extremely irritating to the eyes and skin; exposure leads to delayed vesication and swelling of the skin; inhalation of MCA produces irritation to the mucosa of the upper respiratory tract. MCA has been shown to be an initiator of tumours in mouse skin; MCA may therefore be considered as a presumptive tumorigen, even though it was negative in Ames mutagenicity tests. It is recommended that direct contact with liquid and vapours be prevented through strict engineering controls and that air concentrations be kept below 1ppm as a ceiling concentration.
Descriptors (primary) threshold limit values; monochloroacetone; hazard evaluation; fungicides; toxicology
Descriptors (secondary) plastics industry; cosmetics industry; pharmaceutical industry
Document type D - Periodical articles
Subject(s) Toxic and dangerous substances
Broad subject area(s)
Browse category(ies) Risk evaluation
Agricultural chemicals
Occupational exposure limits