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Document ID (ISN)46319
CIS number 86-1090
ISSN - Serial title 0323-9179 - Problemi na higienata
Year 1984
Convention or series no.
Author(s) Vergieva T.
Title Experimental study on Endodan for teratogenicity and embryotoxicity
Original title Eksperimentalno proučvane na endodan za teratogennost i embriotoksičnost [in Bulgarian]
Bibliographic information July 1984, Vol.9, p.88-95. Illus. 13 ref.
Abstract An experiment was carried out on albino rats for assessment of the effect, during gestation, of the fungicide endodan (ethylene-thiuram monosulfide) on the intrauterine and postnatal development of the progeny. A low teratogenic and embryotoxic activity was found after a single treatment with 1/2LD50 on the 13th day of gestation. The preparation has a pronounced cumulative effect on daily administration of 1/5, 1/10 and 1/20LD50, manifested by clinical symptoms and death of a part of the pregnant animals. Behavioural abnormalities were observed in the progeny but no changes in viability and weight gain during the postnatal period.
Descriptors (primary) embryotoxic effects; endodan; thioamides; teratogenic effects; fungicides
Descriptors (secondary) nervous function tests; mortality; cumulative properties; animal experiments; perceptual-motor performance tests; toxicity evaluation
Document type D - Periodical articles
Subject(s) Occupational pathology
Broad subject area(s)
Browse category(ies) Antifertility and prenatal effects
Amides
Agricultural chemicals
Genetic factors in reaction to exposures