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CISDOC database

Document ID (ISN)46115
CIS number 86-1002
Year 1985
Convention or series no. Environmental Health Criteria 56
Title Propylene Oxide
Bibliographic information World Health Organization, Distribution and Sales Service, 1211 Genčve 27, Switzerland, 1985. 53p. 99 ref. Price: SF.8.00.
Abstract Exposure of man to propylene oxide mainly occurs through inhalation at the workplace. Taking into account the body of available data - the alkylating nature of propylene oxide, the formation of DNA adducts, the positive response in in vitro mutagenesis assays, the carcinogenic effects in animals at the sites of entry into the body, and the absence of adequate data on cancer in human beings - propylene oxide should be regarded as if it presented a carcinogenic risk for man, and levels in the environment should be kept as low as feasible.
Descriptors (primary) toxicology; hazard evaluation; propylene oxide
Descriptors (secondary) mutagenic effects; carcinogenic effects; animal experiments
Document type E - Books, reports, proceedings
Subject(s) Toxic and dangerous substances
Broad subject area(s)
Browse category(ies) Risk evaluation
Ethers
Ethylene oxide
Genetic factors in reaction to exposures