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Document ID (ISN)45838
CIS number 86-683
ISBN(s) 91-7464-247-2
Year 1985
Convention or series no. Arbete och Hälsa 1985:4
Author(s) Alexander J.
Title Nordic Expert Group for Documentation of Threshold Limit Values - 55. Acrylonitrile
Original title Nordiska expertgruppen för gränsvärdesdokumentation - 55. Akrylonitril [in Norwegian]
Bibliographic information Arbetarskyddsstyrelsen, Publikationsservice, 171 84 Solna, Sweden, 1985. 54p. Illus. 125 ref.
Abstract The acute toxicity of acrylonitrile is relatively high in tests on animals. The first acute symptoms produced at low concentrations include eye irritation, sneezing, headache, nausea, weakness and vomiting. Acute exposure to higher concentrations causes profound weakness, respiratory distress and asphyxia. Acrylonitrile can be absorbed through the skin. Metabolism of acrylonitrile liberates cyanide. Acrylonitrile is teratogenic in rats and hamsters. Acrylonitrile is mutagenic, induces breaks in DNA strands and causes unscheduled DNA synthesis, sister chromatid exchange and cell transformation. Acrylonitrile is carcinogenic in rats. Epidemiological studies of workers exposed to acrylonitrile supply limited, although consistent, evidence of carcinogenicity in human. Thus, the carcinogenic properties of acrylonitrile should be the biological effects used in establishing an occupational exposure limit.
Descriptors (primary) mutagenic effects; threshold limit values; acrylonitrile; irritation; carcinogenic effects; genetic effects; teratogenic effects; cyanogenic effects; toxicology
Descriptors (secondary) determination of exposure limits; literature survey
Document type E - Books, reports, proceedings
Subject(s) Toxic and dangerous substances
Broad subject area(s)
Browse category(ies) Antifertility and prenatal effects
Cyano compounds
Genetic factors in reaction to exposures
Occupational exposure limits