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Document ID (ISN)45565
CIS number 86-398
ISBN(s) 91-7464-266-9
Year 1985
Convention or series no. Arbete och Hälsa 1985:23
Author(s) Ehlert Knudsen L.
Title Nordic Expert Group for Documentation of Threshold Limit Values - 60. Propylene oxide
Original title Nordiska expertgruppen för gränsvärdesdokumentation - 60. Propylenoxid [in Danish]
Bibliographic information Arbetarskyddsstyrelsen, Publikationsservice, 171 84 Solna, Sweden, 1985. 43p. 89 ref.
Abstract A critical survey and evaluation of the relevant literature as the basis for determination of an occupational exposure limit for propylene oxide. Propylene oxide is a highly reactive, electrophilic substance, which reacts with cellular macromolecules such as RNA, DNA and proteins, by alkylating nucleophilic centres. Propylene oxide is a mutagen. It induces local tumours when inhaled or administered by subcutaneous and intragastric routes and has an adverse effect on male and female reproduction in animals (mice and rats). In 1984, a working group in the IARC determined that there was sufficient evidence for the carcinogenicity of propylene oxide in experimental animals. Propylene oxide is an allergic sensitiser. It is recommended that the genotoxic and carcinogenic effects serve as the biological effects to be used as a basis for an evaluation in setting an occupational exposure limit for propylene oxide.
Descriptors (primary) mutagenic effects; threshold limit values; antifertility effects; sensitization; propylene oxide; carcinogenic effects; toxicology
Descriptors (secondary) determination of exposure limits; literature survey
Document type E - Books, reports, proceedings
Subject(s) Toxic and dangerous substances
Broad subject area(s)
Browse category(ies) Antifertility and prenatal effects
Occupational exposure limits
Ethers
Ethylene oxide
Genetic factors in reaction to exposures