|Document ID (ISN)||45565|
|Convention or series no.
||Arbete och Hälsa 1985:23
||Ehlert Knudsen L.
||Nordic Expert Group for Documentation of Threshold Limit Values - 60. Propylene oxide
||Nordiska expertgruppen för gränsvärdesdokumentation - 60. Propylenoxid [in Danish]|
||Arbetarskyddsstyrelsen, Publikationsservice, 171 84 Solna, Sweden, 1985. 43p. 89 ref.
||A critical survey and evaluation of the relevant literature as the basis for determination of an occupational exposure limit for propylene oxide. Propylene oxide is a highly reactive, electrophilic substance, which reacts with cellular macromolecules such as RNA, DNA and proteins, by alkylating nucleophilic centres. Propylene oxide is a mutagen. It induces local tumours when inhaled or administered by subcutaneous and intragastric routes and has an adverse effect on male and female reproduction in animals (mice and rats). In 1984, a working group in the IARC determined that there was sufficient evidence for the carcinogenicity of propylene oxide in experimental animals. Propylene oxide is an allergic sensitiser. It is recommended that the genotoxic and carcinogenic effects serve as the biological effects to be used as a basis for an evaluation in setting an occupational exposure limit for propylene oxide.
||mutagenic effects; threshold limit values; antifertility effects; sensitization; propylene oxide; carcinogenic effects; toxicology
||determination of exposure limits; literature survey
||E - Books, reports, proceedings
||Toxic and dangerous substances
|Broad subject area(s)
||Antifertility and prenatal effects
Occupational exposure limits
Genetic factors in reaction to exposures