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Document ID (ISN)45354
CIS number 86-108
ISSN - Serial title 0016-9900 - Gigiena i sanitarija
Year 1984
Convention or series no.
Author(s) Karpenko V.N., Hohol'kova G.A., Pokrovskaja T.N., Rjazanova R.A., Gricevskaja I.D.
Title Bases for the hygienic characterisation of the pesticide kroneton
Original title Materialy k gigieničeskoj harakteristike pesticida kronetona [in Russian]
Bibliographic information Oct. 1984, No.10, p.23-26. 6 ref.
Abstract The carbamate insecticide kroneton (2-(ethylthiomethyl)phenyl N-methylcarbamate) was subjected to a typical battery of toxicological tests. A single intragastric dose is moderately toxic for rats (LD50=400-500mg/kg) and highly toxic for mice and rabbits (LD50=150 and 118mg/kg, respectively). The pesticide has weakly cumulative effects. Its principal mode of action is inhibition of cholinesterase. It penetrates intact skin, producing embryotoxic, gonadotoxic and mutagenic effects. A subthreshold chronic dose is 0.043mg/kg at a concentration of 0.34mg/m3. A MAC for workplace air of 0.05mg/m3 is proposed. Work with the pesticide should be conducted with the same precautions as for highly toxic carbamate and organophosphorus pesticides.
Descriptors (primary) neurotoxic effects; threshold limit values; enzyme inhibition; USSR; skin absorption; carbamates; insecticides; toxicology; kroneton
Descriptors (secondary) mutagenic effects; animal experiments; embryotoxic effects
Document type D - Periodical articles
Subject(s) Toxic and dangerous substances
Broad subject area(s)
Browse category(ies) Blood diseases
Diseases of the nervous system
Amides
Genetic factors in reaction to exposures
Agricultural chemicals
Occupational exposure limits