| Document ID (ISN) | 45354 |
| CIS number |
86-108 |
| ISSN - Serial title |
0016-9900 - Gigiena i sanitarija |
| Year |
1984 |
| Convention or series no. |
|
| Author(s) |
Karpenko V.N., Hohol'kova G.A., Pokrovskaja T.N., Rjazanova R.A., Gricevskaja I.D. |
| Title |
Bases for the hygienic characterisation of the pesticide kroneton |
| Original title |
Materialy k gigieničeskoj harakteristike pesticida kronetona [in Russian] |
| Bibliographic information |
Oct. 1984, No.10, p.23-26. 6 ref. |
| Abstract |
The carbamate insecticide kroneton (2-(ethylthiomethyl)phenyl N-methylcarbamate) was subjected to a typical battery of toxicological tests. A single intragastric dose is moderately toxic for rats (LD50=400-500mg/kg) and highly toxic for mice and rabbits (LD50=150 and 118mg/kg, respectively). The pesticide has weakly cumulative effects. Its principal mode of action is inhibition of cholinesterase. It penetrates intact skin, producing embryotoxic, gonadotoxic and mutagenic effects. A subthreshold chronic dose is 0.043mg/kg at a concentration of 0.34mg/m3. A MAC for workplace air of 0.05mg/m3 is proposed. Work with the pesticide should be conducted with the same precautions as for highly toxic carbamate and organophosphorus pesticides. |
| Descriptors (primary) |
neurotoxic effects; threshold limit values; enzyme inhibition; USSR; skin absorption; carbamates; insecticides; toxicology; kroneton |
| Descriptors (secondary) |
mutagenic effects; animal experiments; embryotoxic effects |
| Document type |
D - Periodical articles |
| Subject(s) |
Toxic and dangerous substances
|
| Broad subject area(s) |
|
| Browse category(ies) |
Blood diseases
Diseases of the nervous system
Amides
Genetic factors in reaction to exposures
Agricultural chemicals
Occupational exposure limits
|
