|Document ID (ISN)||45354|
|ISSN - Serial title
||0016-9900 - Gigiena i sanitarija
|Convention or series no.
||Karpenko V.N., Hohol'kova G.A., Pokrovskaja T.N., Rjazanova R.A., Gricevskaja I.D.
||Bases for the hygienic characterisation of the pesticide kroneton
||Materialy k gigieničeskoj harakteristike pesticida kronetona [in Russian]|
||Oct. 1984, No.10, p.23-26. 6 ref.
||The carbamate insecticide kroneton (2-(ethylthiomethyl)phenyl N-methylcarbamate) was subjected to a typical battery of toxicological tests. A single intragastric dose is moderately toxic for rats (LD50=400-500mg/kg) and highly toxic for mice and rabbits (LD50=150 and 118mg/kg, respectively). The pesticide has weakly cumulative effects. Its principal mode of action is inhibition of cholinesterase. It penetrates intact skin, producing embryotoxic, gonadotoxic and mutagenic effects. A subthreshold chronic dose is 0.043mg/kg at a concentration of 0.34mg/m3. A MAC for workplace air of 0.05mg/m3 is proposed. Work with the pesticide should be conducted with the same precautions as for highly toxic carbamate and organophosphorus pesticides.
||neurotoxic effects; threshold limit values; enzyme inhibition; USSR; skin absorption; carbamates; insecticides; toxicology; kroneton
||mutagenic effects; animal experiments; embryotoxic effects
||D - Periodical articles
||Toxic and dangerous substances
|Broad subject area(s)
Diseases of the nervous system
Genetic factors in reaction to exposures
Occupational exposure limits