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CISDOC database
Document ID (ISN) | 45348 |
CIS number |
86-257 |
ISSN - Serial title |
0140-6736 - Lancet |
Year |
1985 |
Convention or series no. |
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Author(s) |
Ndumbe P.M., Cradock-Watson J.E., MacQueen S., Dunn H., Holzel H., André F., Davies E.G., Dudgeon J.A., Levinsky R.J. |
Title |
Immunisation of nurses with a live varicella vaccine |
Bibliographic information |
18 May 1985, Vol.1, No.8434, p.1144-1147. 22 ref. |
Abstract |
34 nurses with no history of chickenpox and who were seronegative to varicella zoster virus (VZV) were immunised with a live attenuated varicella vaccine (OKA-RIT strain) and were followed up for up to 3 years. There were no major reactions to the vaccine. After 1 year, 94% of the nurses had antibodies to VZV, but after 3 years only 64% had them. 2 of 13 vaccinated nurses who looked after children with chickenpox became infected, but 1 of them had never seroconverted. 6 out of 7 unvaccinated nurses who were exposed to chickenpox developed the disease. Thus this strain of VZV vaccine is shown to be safe and immunogenic in adults likely to be exposed to chickenpox. These tests also showed that both cell-mediated and antibody tests are needed for long-term assessment of immunity to chickenpox after vaccination. |
Descriptors (primary) |
chickenpox; vaccination; immunization; hospitals |
Descriptors (secondary) |
serological reactions; infectious diseases |
Document type |
D - Periodical articles |
Subject(s) |
Commerce, services, offices
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Broad subject area(s) |
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Browse category(ies) |
Skin diseases Health care services Bacterial and parasitic diseases Viral diseases (other than aids)
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