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Document ID (ISN)45348
CIS number 86-257
ISSN - Serial title 0140-6736 - Lancet
Year 1985
Convention or series no.
Author(s) Ndumbe P.M., Cradock-Watson J.E., MacQueen S., Dunn H., Holzel H., AndrÚ F., Davies E.G., Dudgeon J.A., Levinsky R.J.
Title Immunisation of nurses with a live varicella vaccine
Bibliographic information 18 May 1985, Vol.1, No.8434, p.1144-1147. 22 ref.
Abstract 34 nurses with no history of chickenpox and who were seronegative to varicella zoster virus (VZV) were immunised with a live attenuated varicella vaccine (OKA-RIT strain) and were followed up for up to 3 years. There were no major reactions to the vaccine. After 1 year, 94% of the nurses had antibodies to VZV, but after 3 years only 64% had them. 2 of 13 vaccinated nurses who looked after children with chickenpox became infected, but 1 of them had never seroconverted. 6 out of 7 unvaccinated nurses who were exposed to chickenpox developed the disease. Thus this strain of VZV vaccine is shown to be safe and immunogenic in adults likely to be exposed to chickenpox. These tests also showed that both cell-mediated and antibody tests are needed for long-term assessment of immunity to chickenpox after vaccination.
Descriptors (primary) chickenpox; vaccination; immunization; hospitals
Descriptors (secondary) serological reactions; infectious diseases
Document type D - Periodical articles
Subject(s) Commerce, services, offices
Broad subject area(s)
Browse category(ies) Skin diseases
Health care services
Bacterial and parasitic diseases
Viral diseases (other than aids)