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Document ID (ISN)45106
CIS number 85-1849
ISSN - Serial title 0016-9900 - Gigiena i sanitarija
Year 1984
Convention or series no.
Author(s) Merkur'eva R.V., Aulika B.V., Bazeljuk L.T., Jakimova E.R., Dolinskaja S.I., Konstantinova I.N., Astahova L.F.
Title Changes in alveolar and peritoneal macrophage function in rats exposed to quartz dust
Original title Izmenenie funkcional'nogo sostojanija al'veoljarnyh i peritoneal'nyh makrofagov krys pri dejstvii kvarcevoj pyli [in Russian]
Bibliographic information June 1984, No.6, p.16-18. 15 ref.
Abstract Intratracheal administration of 50mg of 1-2Ám quartz dust (92.8% free silica) to rats produced morphological and metabolic changes in alveolar macrophages within 24h: lysosomal and cell membranes were labilised, and activities of metabolically important enzymes were altered; the changes became more marked 48 and 72h after treatment, and macrophage mortality increased. Intraperitoneal administration of 30mg of the same dust had similar effects on peritoneal macrophages, but effects took longer to develop. These observations may have diagnostic value.
Descriptors (primary) macrophages; silica; respirable dust; metabolic disturbances; enzyme disturbances
Descriptors (secondary) animal experiments
Document type D - Periodical articles
Subject(s) Dust, aerosols and related diseases
Broad subject area(s)
Browse category(ies) Endocrine diseases
Blood diseases