| Document ID (ISN) | 44919 |
| CIS number |
85-1930 |
| ISSN - Serial title |
Gigiena truda i professional'nye zabolevanija |
| Year |
1984 |
| Convention or series no. |
|
| Author(s) |
Belova I.Ju., Rafikov H.S., Husnutdinova Ė.K., Vasanova N.I., Ivaško G.A., Škuratov I.I. |
| Title |
Quantitative features of the activity of lactate dehydrogenase isoenzymes in the blood serum of workers engaged in the production of chlorinated organic pesticides |
| Original title |
Količestvennoe projavlenie aktivnosti izofermentov laktatdegidrogenazy v syvorotke krovi rabočyh, zanjatyh na proizvodstve hlororganičeskih pesticidov [in Russian] |
| Bibliographic information |
Feb. 1984, No.2, p.30-34. 13 ref. |
| Abstract |
Lactate dehydrogenase (LDH) is an enzyme made up of 4 protein chains. There are 2 genes (A and B) for these proteins. An LDH molecule can consist of 4 A-gene products, 3 A-gene products and a B-gene product, 2 of each, etc. There is a spectrum of these isoenzymes typical of healthy humans. When the LDH of workers in a chlorinated organic herbicide plant was examined, altered isoenzyme spectra were observed, even in workers with less than 5 years at the plant. The alterations imply that environmental factors at the plant activate gene B and inhibit gene A. |
| Descriptors (primary) |
herbicides; chlorinated organic compounds; pesticide production; genetic effects; enzyme disturbances |
| Descriptors (secondary) |
isoenzymes; lactate dehydrogenase |
| Document type |
D - Periodical articles |
| Subject(s) |
Occupational pathology
|
| Broad subject area(s) |
|
| Browse category(ies) |
Agricultural chemicals
Chemical industry
Genetic factors in reaction to exposures
Antifertility and prenatal effects
Blood diseases
|
