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Document ID (ISN)44919
CIS number 85-1930
ISSN - Serial title Gigiena truda i professional'nye zabolevanija
Year 1984
Convention or series no.
Author(s) Belova I.Ju., Rafikov H.S., Husnutdinova Ė.K., Vasanova N.I., Ivaško G.A., Škuratov I.I.
Title Quantitative features of the activity of lactate dehydrogenase isoenzymes in the blood serum of workers engaged in the production of chlorinated organic pesticides
Original title Količestvennoe projavlenie aktivnosti izofermentov laktatdegidrogenazy v syvorotke krovi rabočyh, zanjatyh na proizvodstve hlororganičeskih pesticidov [in Russian]
Bibliographic information Feb. 1984, No.2, p.30-34. 13 ref.
Abstract Lactate dehydrogenase (LDH) is an enzyme made up of 4 protein chains. There are 2 genes (A and B) for these proteins. An LDH molecule can consist of 4 A-gene products, 3 A-gene products and a B-gene product, 2 of each, etc. There is a spectrum of these isoenzymes typical of healthy humans. When the LDH of workers in a chlorinated organic herbicide plant was examined, altered isoenzyme spectra were observed, even in workers with less than 5 years at the plant. The alterations imply that environmental factors at the plant activate gene B and inhibit gene A.
Descriptors (primary) herbicides; chlorinated organic compounds; pesticide production; genetic effects; enzyme disturbances
Descriptors (secondary) isoenzymes; lactate dehydrogenase
Document type D - Periodical articles
Subject(s) Occupational pathology
Broad subject area(s)
Browse category(ies) Blood diseases
Antifertility and prenatal effects
Chemical industry
Agricultural chemicals
Genetic factors in reaction to exposures