|Document ID (ISN)||44919|
|ISSN - Serial title
||Gigiena truda i professional'nye zabolevanija
|Convention or series no.
||Belova I.Ju., Rafikov H.S., Husnutdinova Ė.K., Vasanova N.I., Ivaško G.A., Škuratov I.I.
||Quantitative features of the activity of lactate dehydrogenase isoenzymes in the blood serum of workers engaged in the production of chlorinated organic pesticides
||Količestvennoe projavlenie aktivnosti izofermentov laktatdegidrogenazy v syvorotke krovi rabočyh, zanjatyh na proizvodstve hlororganičeskih pesticidov [in Russian]|
||Feb. 1984, No.2, p.30-34. 13 ref.
||Lactate dehydrogenase (LDH) is an enzyme made up of 4 protein chains. There are 2 genes (A and B) for these proteins. An LDH molecule can consist of 4 A-gene products, 3 A-gene products and a B-gene product, 2 of each, etc. There is a spectrum of these isoenzymes typical of healthy humans. When the LDH of workers in a chlorinated organic herbicide plant was examined, altered isoenzyme spectra were observed, even in workers with less than 5 years at the plant. The alterations imply that environmental factors at the plant activate gene B and inhibit gene A.
||herbicides; chlorinated organic compounds; pesticide production; genetic effects; enzyme disturbances
||isoenzymes; lactate dehydrogenase
||D - Periodical articles
|Broad subject area(s)
Antifertility and prenatal effects
Genetic factors in reaction to exposures