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Document ID (ISN)44914
CIS number 85-1928
ISSN - Serial title 0049-8610 - Zeitschrift fŘr die gesamte Hygiene und ihre Grenzgebiete
Year 1984
Convention or series no.
Author(s) Ellinger C.
Title Is dichlorvos hepatotoxic?
Original title Ist Dichlorvos hepatotoxisch? [in German]
Bibliographic information 1984, Vol.30, No.3, p.156-158. Illus. 59 ref.
Abstract Administration of dichlorvos to rats at the LD50 (70mg/kg) produced a mild hepatosis. Chronic administration of the compound (30mg/kg/day for 90 days) lowered the free fatty acid content and raised the phosphatide content of female rats. Male rats did not show this alteration in lipid composition, but did have elevated levels of hepatic cytochrome P-450 and O-demethylase. These observations and literature data suggest that the hepatotoxicity of dichlorvos is low, but that heavily exposed persons should receive medical care that takes account of the exposure.
Descriptors (primary) hepatotoxic effects; toxicology; pesticides; dichlorvos
Descriptors (secondary) animal experiments
Document type D - Periodical articles
Subject(s) Occupational pathology
Broad subject area(s)
Browse category(ies) Esters and salts
Agricultural chemicals