Document ID (ISN) | 44608 |
CIS number |
85-1605 |
ISSN - Serial title |
Gigiena truda i professional'nye zabolevanija |
Year |
1984 |
Convention or series no. |
|
Author(s) |
Tatevosjan A.Ė., Sahkaljan Ė.O. |
Title |
Experimental bases for a MAC for the acaricide Plictran in workplace air |
Original title |
Materialy k ėksperimental'nomu obosnovaniju PDK akaricida pliktrana v vozduhe rabočej zony [in Russian] |
Bibliographic information |
May 1984, No.5, p.52-53. 5 ref. |
Abstract |
A standard battery of toxicological tests showed Plictran (tricyclohexyltin hydroxide) to be moderately toxic: intragastric LD50=318, 275 and 458mg/kg for rats, mice and rabbits, respectively; topical LD50 = 1880 and 2422mg/kg for rats and rabbits respectively; inhalation CL50=244 and 290mg/m3 for rats and mice, respectively. The threshold of acute toxicity (kidney damage) was about 6.5mg/m3. Plictran was not allergenic or sensitising, but was an irritant. Chronic exposure to 0.170mg/m3 did not produce embryotropic or teratogenic effects; this concentration may be taken as a threshold for such effects. A MAC of 0.02mg/m3 should be established for Plictran production facilities; the standard should carry the warning "skin absorption". |
Descriptors (primary) |
threshold limit values; irritants; USSR; renal damage; acaricides; toxicology; tricyclohexyltin hydroxide |
Descriptors (secondary) |
animal experiments |
Document type |
D - Periodical articles |
Subject(s) |
Toxic and dangerous substances
|
Broad subject area(s) |
|
Browse category(ies) |
Diseases of the kidney and the urinary system Agricultural chemicals Occupational exposure limits
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