ILO Home
Go to the home page
Site map | Contact us Franšais | Espa˝ol

CISDOC database

Document ID (ISN)44602
CIS number 85-1648
ISSN - Serial title Gigiena truda i professional'nye zabolevanija
Year 1984
Convention or series no.
Author(s) Gončarova L.N., Čirkov V.V., Rudakova L.E.
Title Effect of acrylonitrile production on the function of some endocrine glands
Original title Vlijanie proizvodstva nitrila akrilovoj kisloty na funkciju nekotoryh želez vnutrennej sekrecii [in Russian]
Bibliographic information May 1984, No.5, p.23-25. 7 ref.
Abstract The functional state of the pituitary-thyroid system and the glucocorticoid function of the adrenals were determined in 123 workers with different lengths of exposure to acrylonitrile. Thyrotropic hormone, triiodothyronine and total and bound thyroxine were determined in the blood of the subjects, and the iodine-binding function of the thyroid was tested with the radioisotope iodine-131. Clinical examinations were also carried out. Acrylonitrile (and the prussic acid that is frequently present with it) apparently inhibits thyroid function, even at low levels. The effect increases with length of exposure. The reduced level of thyroid hormones stimulates the production of thyrotropin, which entails enlargement of the thyroid. Blood cortisol levels were highly variable, but tended to decrease with length of service.
Descriptors (primary) chemical industry; thyroid disorders; adrenal gland disorders; acrylonitrile
Descriptors (secondary) length of exposure; hydrocyanic acid
Document type D - Periodical articles
Subject(s) Occupational pathology
Broad subject area(s)
Browse category(ies) Endocrine diseases
Cyano compounds
Chemical industry