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Document ID (ISN)44522
CIS number 85-1402
ISSN - Serial title 0016-9900 - Gigiena i sanitarija
Year 1984
Convention or series no.
Author(s) Kagan Ju.S., Pan'šina T.N., Vojtenko G.A., Sasinovič L.M., Rodionov G.A., Voronina V.M., Kokšareva N.V., Šuljak V.G., Deši I., Karmoš-Varsegi M., Štromajer A.
Title Toxicology of the pesticide Hostaquick and establishment of a safe exposure level
Original title Toksikologija pesticida hostakvika i ustanovlenie bezopasnyh urovnej ego vozdejstvija [in Russian]
Bibliographic information Apr. 1984, No.4, p.18-22. Illus. 3 ref.
Abstract In a battery of toxicological tests with rats, mice and guinea pigs, the systemic insecticide Hostaquick was found to be highly toxic and mildly cumulative. Its basic mechanism of action is inhibition of cholinesterases in the blood, and other tissues. Changes in the functional states of the central nervous system, liver and peripheral blood are sensitive indicators of Hostaquick intoxication. The anticholinesterase activity of the compound is more marked on continuous administration via the respiratory tract than on periodic administration, although the latter protocol produces a greater sensitising effect. Extrapolation of the data to man gives a daily exposure limit of 0.003mg/kg and a recommended MAC under agricultural conditions of 0.5mg/m3.
Descriptors (primary) neurotoxic effects; threshold limit values; enzyme inhibition; USSR; haematotoxic effects; Hostaquick; insecticides; toxicology; hepatotoxic effects
Descriptors (secondary) animal experiments; cholinesterase
Document type D - Periodical articles
Subject(s) Agriculture, fishing, animal husbandry
Broad subject area(s)
Browse category(ies) Blood diseases
Diseases of the nervous system
Esters and salts
Toxicology
Agricultural chemicals
Occupational exposure limits