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Document ID (ISN)44267
CIS number 85-1074
ISSN - Serial title 0025-7818 - Medicina del lavoro
Year 1984
Convention or series no.
Author(s) Lu Y.P., Lu P.K., Xue S.Z., Gu X.Q.
Title Investigation on the chronic effects of Dipterex in occupational exposure
Bibliographic information Sep.-Oct. 1984, Vol.75, No.5, p.376-384. Illus. 11 ref.
Abstract 110 Chinese workers engaged in refining Dipterex (chlorophos) for veterinary medicine and 75 controls were examined for physiological and neurological symptoms, electroencephalographic (EEG) abnormalities and lowered blood cholinesterase (ChE) activity. Median exposure levels were 0.52-1.54mg/m3. Symptoms affecting more than half the exposed workers during the period of exposure were muscular twitching, lightheadedness, breathlessness and sweating. 4 months after exposure, lightheadedness remained as the only prominent symptom. EEG abnormalities occurred among 35.5% of the workers during exposure, 29.3% of the workers 4 months after exposure, and among 8% of the controls. Reduced blood ChE activity was significant during exposure, but not 4 months after exposure or in the control group. EEG examinations are recommended as the best method for monitoring exposure to Dipterex. It is suggested that the current MAC value in China (1mg/m3) be reduced.
Descriptors (primary) neurotoxic effects; pesticides; chlorophos; exposure tests; biological effects
Descriptors (secondary) cholinesterase monitoring; China; long-term exposure; organophosphorus compounds; electroencephalographic changes; threshold limit values
Document type D - Periodical articles
Subject(s) Occupational pathology
Broad subject area(s)
Browse category(ies) Diseases of the nervous system
Esters and salts
Agricultural chemicals
Biological monitoring