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Document ID (ISN)44232
CIS number 85-1066
ISSN - Serial title 0021-5082 - Japanese Journal of Hygiene - Nihon Eiseigaku Zasshi
Year 1984
Convention or series no.
Author(s) Yamauchi T., Konno N., Yamaguchi Y., Fukushima M.
Title Intensifying effect of repeated pretreatment on the delayed neurotoxicity of the organophosphorus insecticide cyanofenphos in hens
Bibliographic information Aug. 1984, Vol.39, No.3, p.611-620. Illus. 15 ref.
Abstract Pretreatment for 8 days with small doses (10mg/kg/day) of cyanofenphos (CYP), an organophosphorus insecticide which shows delayed neurotoxicity, first protected hens from the acute intoxication due to a subsequent large dose (100-1600mg/kg) of CYP. However, the pretreated hens suffered severer effects than hens which received only challenge doses, unless the challenge doses were greater than 800mg/kg. These results warn that factory workers or farmers who are exposed repeatedly to low levels of neurotoxic organophosphorus insecticides may be affected by more severe neuropathy than usual if they are accidentally exposed to high concentrations of these insecticides.
Descriptors (primary) neurotoxic effects; organophosphorus compounds; subthreshold exposure; delayed effects; insecticides
Descriptors (secondary) cyanophenphos; animal experiments
Document type D - Periodical articles
Subject(s) Occupational pathology
Broad subject area(s)
Browse category(ies) Agricultural chemicals
Diseases of the nervous system