| Document ID (ISN) | 43884 |
| CIS number |
85-762 |
| ISSN - Serial title |
0007-1072 - British Journal of Industrial Medicine |
| Year |
1984 |
| Convention or series no. |
|
| Author(s) |
Candura F., Moscato G. |
| Title |
Do amines induce occupational asthma in workers manufacturing polyurethane foams? |
| Bibliographic information |
Nov. 1984, Vol.41, No.4, p.552-553. Illus. 10 ref. |
| Abstract |
12 workers occupationally exposed to polyurethane foams and with symptoms of wheezing and breathlessness were subjected to a bronchial provocation test with methacholine (to establish a dose-response curve), toluenediisocyanate (TDI) at 0.01ppm, and toluenediamine (TDA) at 1.31mg/m3 and at 3.21mg/m3. High sensitivity to methacholine (positive response below 1000g administered) was shown in 10 subjects. All the subjects had positive reactions to TDI, and none of them responded to TDA at either concentration. These data suggest that TDI is the agent for the respiratory symptoms, and that TDA does not produce asthma. |
| Descriptors (primary) |
polyurethanes; diaminotoluenes; allergic asthma; tolylene diisocyanate; amines |
| Descriptors (secondary) |
2,4-diaminotoluene; 2,4-tolylene diisocyanate; allergic respiratory disorders; expanded plastics; inhalation tests; methacholine |
| Document type |
D - Periodical articles |
| Subject(s) |
Occupational pathology
|
| Broad subject area(s) |
|
| Browse category(ies) |
Aromatic amines
Cyano compounds
Allergies
Diseases of the respiratory system (except for pneumoconiosis & similar)
Isocyanates
|
