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CISDOC database
| Document ID (ISN) | 43881 |
| CIS number |
85-759 |
| ISSN - Serial title |
0007-1072 - British Journal of Industrial Medicine |
| Year |
1984 |
| Convention or series no. |
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| Author(s) |
Mutti A., Falzoi M., Lucertini S., Arfini G., Zignani M., Lombardi S., Franchini I. |
| Title |
n-Hexane metabolism in occupationally exposed workers |
| Bibliographic information |
Nov. 1984, Vol.41, No.4, p.533-538. Illus. 16 ref. |
| Abstract |
This study was conducted on 10 workers in a shoe factory. The n-hexane concentrations in the workplace air ranged from 8-1143mg/m3 over 8h, with a median concentration of 243mg/m3. Alveolar retention of n-hexane was about 25%, corresponding to a lung uptake of 17%. Post-exposure alveolar excretion (monitored for 6h) was about 10% of the total uptake. The main metabolites of n-hexane were determined in urine samples collected before, at the end, and 15h after the work shift. Urinary concentrations were low, though related to original n-hexane concentrations in air. The best estimate of overall exposure was provided by end-of-shift concentrations of 2,5-hexanedione, 3mg/g creatinine of which would correspond to ab. 50ppm of n-hexane in air (mean daily exposure). |
| Descriptors (primary) |
hexane; organic solvents; shoe industry; exposure tests; urinary metabolites |
| Descriptors (secondary) |
metabolic process; determination in urine; alveolar clearance; 2,5-hexanedione |
| Document type |
D - Periodical articles |
| Subject(s) |
Occupational pathology
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| Broad subject area(s) |
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| Browse category(ies) |
Footwear, leather and fur industry
Biological monitoring
Aliphatic and alicyclic hydrocarbons
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