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Document ID (ISN)43823
CIS number 85-749
ISSN - Serial title 0044-2178 - Zeitschrift für ärztliche Fortbildung
Year 1984
Convention or series no.
Author(s) Lohs K.
Title Delayed neurotoxic lesions due to organophosphorus compounds
Original title Neurotoxische Spätschäden phosphororganischer Verbindungen [in German]
Bibliographic information 1984, Vol.78, No.14, p.593-596. 17 ref.
Abstract Review of the problems connected with the delayed neurotoxic lesions that can be produced by organophosphorus compounds. The problems have been known for 80 years, but, in spite of the documentation of more than 40,000 cases of human poisoning, no clear structure-effect relationships have yet been established. Triorthocresyl phosphate and parathion poisonings are taken as typical examples. The biochemical mechanisms underlying delayed lesions remain unknown. There may be a neurotoxic esterase different from the cholinesterases. Delayed neuropathy may be directly related to phosphorylation of this esterase.
Descriptors (primary) neurotoxic effects; poisoning; delayed effects; pesticides; organophosphorus compounds
Descriptors (secondary) parathion; triorthocresyl phosphate; phosphoric acid esters
Document type D - Periodical articles
Subject(s) Occupational pathology
Broad subject area(s)
Browse category(ies) Agricultural chemicals
Diseases of the nervous system