| Document ID (ISN) | 43801 |
| CIS number |
85-746 |
| ISSN - Serial title |
0301-1542 - Japanese Journal of Thoracic Diseases |
| Year |
1984 |
| Convention or series no. |
|
| Author(s) |
Ishihara Y., Kitamura S., Takaku F. |
| Title |
Chronic effects of diesel-engine exhaust gas on metabolic functions in rat lungs |
| Bibliographic information |
Mar. 1984, Vol.22, No.3, p.190-196. Illus. 11 ref. |
| Abstract |
Rats were exposed to diesel-engine exhaust gas for periods of from 1 week to 6 months. Rats were classified into 3 groups, i.e. control group, filtered exhaust gas (FEG) group and exhaust gas (EG) group. The sensitivity to acetylcholine of tracheal strips of rats of FEG and EG groups showed a significant increase compared with that of the control group. Inactivation of serotonin, PGE2 and PGF2α in isolated perfused lung lobes in EG and FEG groups exposed for 6 months showed a decrease compared with that in the control group. Plasma level of histamine in EG and FEG groups showed a significant increase compared with that in the control group. The above mentioned results suggest that long-term exposure to diesel-engine exhaust gas may affect pulmonary metabolic functions. |
| Descriptors (primary) |
diesel engines; lung; bronchopulmonary clearance; exhaust gases; metabolic disturbances |
| Descriptors (secondary) |
scintillation scanning; animal experiments |
| Document type |
D - Periodical articles |
| Subject(s) |
Occupational pathology
|
| Broad subject area(s) |
|
| Browse category(ies) |
Endocrine diseases
|
