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Document ID (ISN)43801
CIS number 85-746
ISSN - Serial title 0301-1542 - Japanese Journal of Thoracic Diseases
Year 1984
Convention or series no.
Author(s) Ishihara Y., Kitamura S., Takaku F.
Title Chronic effects of diesel-engine exhaust gas on metabolic functions in rat lungs
Bibliographic information Mar. 1984, Vol.22, No.3, p.190-196. Illus. 11 ref.
Abstract Rats were exposed to diesel-engine exhaust gas for periods of from 1 week to 6 months. Rats were classified into 3 groups, i.e. control group, filtered exhaust gas (FEG) group and exhaust gas (EG) group. The sensitivity to acetylcholine of tracheal strips of rats of FEG and EG groups showed a significant increase compared with that of the control group. Inactivation of serotonin, PGE2 and PGF2α in isolated perfused lung lobes in EG and FEG groups exposed for 6 months showed a decrease compared with that in the control group. Plasma level of histamine in EG and FEG groups showed a significant increase compared with that in the control group. The above mentioned results suggest that long-term exposure to diesel-engine exhaust gas may affect pulmonary metabolic functions.
Descriptors (primary) diesel engines; lung; bronchopulmonary clearance; exhaust gases; metabolic disturbances
Descriptors (secondary) scintillation scanning; animal experiments
Document type D - Periodical articles
Subject(s) Occupational pathology
Broad subject area(s)
Browse category(ies) Endocrine diseases