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Document ID (ISN)43721
CIS number 85-736
ISSN - Serial title 0465-546X - Medicina y seguridad del trabajo
Year 1984
Convention or series no.
Author(s) Harto Castaño A., Pingarrón Carrazón J.M.
Title Thiocyanate determination in blood as an aid in the diagnosis of chronic carbon monoxide poisoning, and as an indicator of tobacco smoking. Description of three determination methods
Original title La tiocianuremia como ayuda al diagnóstico del oxicarbonismo crónico e indicador del tabaquismo. Descripción de tres métodos para su determinación [in Spanish]
Bibliographic information Jan. 1983-Mar. 1984, Vol.31, No.121, p.1-8. Illus. 30 ref.
Abstract Carboxyhaemoglobin (COHb) levels are quite high in smokers; therefore, their determination cannot always be used for the evaluation of carbon monoxide (CO) exposure in the workplace. Hydrogen cyanide, a component of cigarettes, is transformed into thiocyanates by smokers, so that the presence of thiocyanates in blood can be used to distinguish smokers from non-smokers. 3 determination methods for thiocyanates are described, 2 using spectrophotometry, and the 3rd using cathode desorption. Analysing COHb levels and thiocyanate levels as a function of number of cigarettes smoked per day, it is shown that even at 5 cigarettes a day, approx. 50% of the COHb in workers exposed to CO is due to smoking, while at over 30 cigarettes a day, almost all of it is. The level of thiocyanates being directly proportional to the number of cigarettes smoked per day, the level of CO exposure can be calculated from the 2 sets of data.
Descriptors (primary) carbon monoxide; carboxyhaemoglobin level; smoking; thiocyanates
Descriptors (secondary) hydrocyanic acid; description of technique; determination in blood
Document type D - Periodical articles
Subject(s) Occupational pathology
Broad subject area(s)
Browse category(ies) Blood diseases
Carbon monoxide
Inorganic substances
Smoking