|Document ID (ISN)||43721|
|ISSN - Serial title
||0465-546X - Medicina y seguridad del trabajo
|Convention or series no.
||Harto Castaño A., Pingarrón Carrazón J.M.
||Thiocyanate determination in blood as an aid in the diagnosis of chronic carbon monoxide poisoning, and as an indicator of tobacco smoking. Description of three determination methods
||La tiocianuremia como ayuda al diagnóstico del oxicarbonismo crónico e indicador del tabaquismo. Descripción de tres métodos para su determinación [in Spanish]|
||Jan. 1983-Mar. 1984, Vol.31, No.121, p.1-8. Illus. 30 ref.
||Carboxyhaemoglobin (COHb) levels are quite high in smokers; therefore, their determination cannot always be used for the evaluation of carbon monoxide (CO) exposure in the workplace. Hydrogen cyanide, a component of cigarettes, is transformed into thiocyanates by smokers, so that the presence of thiocyanates in blood can be used to distinguish smokers from non-smokers. 3 determination methods for thiocyanates are described, 2 using spectrophotometry, and the 3rd using cathode desorption. Analysing COHb levels and thiocyanate levels as a function of number of cigarettes smoked per day, it is shown that even at 5 cigarettes a day, approx. 50% of the COHb in workers exposed to CO is due to smoking, while at over 30 cigarettes a day, almost all of it is. The level of thiocyanates being directly proportional to the number of cigarettes smoked per day, the level of CO exposure can be calculated from the 2 sets of data.
||carbon monoxide; carboxyhaemoglobin level; smoking; thiocyanates
||hydrocyanic acid; description of technique; determination in blood
||D - Periodical articles
|Broad subject area(s)