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Document ID (ISN)42292
CIS number 84-1361
ISSN - Serial title 0096-1736 - Journal of Occupational Medicine
Year 1983
Convention or series no.
Author(s) Lotti M., Becker C.E., Aminoff M.J., Woodrow J.E., Seiber J.N., Talcott R.E., Richardson R.J.
Title Occupational exposure to the cotton defoliants DEF and merphos - A rational approach to monitoring organophosphorous-induced delayed neurotoxicity
Bibliographic information July 1983, Vol.25, No.7, p.517-522. Illus. 45 ref.
Abstract S,S,S-Tributyl phosphorotrithioate (DEF) and merphos can produce delayed neurotoxicity in animals. Inhibition of the neurotoxic esterase (NTE) in lymphocytes was measured in 7 workers exposed during aerial and ground application of these defoliants in cotton fields, as was peripheral nerve function. The major route of exposure was via the skin. Lymphocyte NTE was affected in exposed workers, according to both intensity and length of exposure. There were no detectable electrophysiological effects. Measurement of NTE in lymphocytes in workers exposed to organophosphates is a rational biomonitor of delayed neuropathy.
Descriptors (primary) neurotoxic effects; cotton farming; exposure tests; defoliants; organophosphorus compounds
Descriptors (secondary) Merphos; lymphocytes; enzyme inhibition; S,S,S-tributyl trithiophosphate; early diagnosis; determination in air; aircraft; conduction velocity; electromyography; delayed effects; dose-response relationship; skin absorption
Document type D - Periodical articles
Subject(s) Occupational pathology
Broad subject area(s)
Browse category(ies) Agricultural chemicals
Biological monitoring
Diseases of the nervous system