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CISDOC database

Document ID (ISN)42181
CIS number 84-1086
Year 1982
Convention or series no. ECETOC Monograph No.4
Title Hepatocarcinogenesis in laboratory rodents: relevance for man
Bibliographic information European Chemical Industry, Ecology and Toxicology Centre, Avenue Louise 250, Boţte 63, 1050 Bruxelles, Belgium, Oct. 1982. 77p. Illus. 253 ref.
Abstract 2 broad mechanisms are considered: in the genotoxic model, chemicals are thought to act by altering the structure of the genetic material of the cell, thus converting it to a cancerous cell; in the non-genotoxic model, the cancer develops from a non-cancerous lesion - involving necrosis, at the subcellular level, or involving hyperplasia. A recommended sequence of steps is given for establishing the hepatocarcinogenic potential of a chemical to laboratory animals and man.
Descriptors (primary) carcinogens; chemical products; extrapolation animal man; animal experiments; liver cancer
Descriptors (secondary) mutagenic effects; metabolic process; enzymes; aflatoxins; genetic effects; steroids; infectious hepatitis; cirrhosis; DNA
Document type E - Books, reports, proceedings
Subject(s) Occupational pathology
Broad subject area(s)
Browse category(ies) Viral diseases (other than aids)
Genetic factors in reaction to exposures
Bacterial and parasitic diseases