| Document ID (ISN) | 42181 |
| CIS number |
84-1086 |
| Year |
1982 |
| Convention or series no. |
ECETOC Monograph No.4
|
| Title |
Hepatocarcinogenesis in laboratory rodents: relevance for man |
| Bibliographic information |
European Chemical Industry, Ecology and Toxicology Centre, Avenue Louise 250, Boîte 63, 1050 Bruxelles, Belgium, Oct. 1982. 77p. Illus. 253 ref. |
| Abstract |
2 broad mechanisms are considered: in the genotoxic model, chemicals are thought to act by altering the structure of the genetic material of the cell, thus converting it to a cancerous cell; in the non-genotoxic model, the cancer develops from a non-cancerous lesion - involving necrosis, at the subcellular level, or involving hyperplasia. A recommended sequence of steps is given for establishing the hepatocarcinogenic potential of a chemical to laboratory animals and man. |
| Descriptors (primary) |
carcinogens; chemical products; extrapolation animal man; animal experiments; liver cancer |
| Descriptors (secondary) |
mutagenic effects; metabolic process; enzymes; aflatoxins; genetic effects; steroids; infectious hepatitis; cirrhosis; DNA |
| Document type |
E - Books, reports, proceedings |
| Subject(s) |
Occupational pathology
|
| Broad subject area(s) |
|
| Browse category(ies) |
Viral diseases (other than aids)
Genetic factors in reaction to exposures
Bacterial and parasitic diseases
|
