|Document ID (ISN)||42181|
|Convention or series no.
||ECETOC Monograph No.4
||Hepatocarcinogenesis in laboratory rodents: relevance for man
||European Chemical Industry, Ecology and Toxicology Centre, Avenue Louise 250, Boţte 63, 1050 Bruxelles, Belgium, Oct. 1982. 77p. Illus. 253 ref.
||2 broad mechanisms are considered: in the genotoxic model, chemicals are thought to act by altering the structure of the genetic material of the cell, thus converting it to a cancerous cell; in the non-genotoxic model, the cancer develops from a non-cancerous lesion - involving necrosis, at the subcellular level, or involving hyperplasia. A recommended sequence of steps is given for establishing the hepatocarcinogenic potential of a chemical to laboratory animals and man.
||carcinogens; chemical products; extrapolation animal man; animal experiments; liver cancer
||mutagenic effects; metabolic process; enzymes; aflatoxins; genetic effects; steroids; infectious hepatitis; cirrhosis; DNA
||E - Books, reports, proceedings
|Broad subject area(s)
||Viral diseases (other than aids)
Genetic factors in reaction to exposures
Bacterial and parasitic diseases