| Document ID (ISN) | 42058 |
| CIS number |
84-1063 |
| ISSN - Serial title |
0355-3140 - Scandinavian Journal of Work, Environment and Health |
| Year |
1983 |
| Convention or series no. |
|
| Author(s) |
Thomas D.C. |
| Title |
Statistical methods for analyzing effects of temporal patterns of exposure on cancer risks |
| Bibliographic information |
Aug. 1983, Vol.9, No.4, p.353-366. Illus. 20 ref. |
| Abstract |
Methods compared are: (1) multivariate logistic analysis incorporating simple exposure indices; and (2) direct fitting to models of the disease process. Case-control data relating lung cancer to asbestos and smoking are used to illustrate the approaches. From approach (1) average age at exposure, age at risk, and duration of exposure contributed direct or interaction effects. In a 2-stage initiation-latency model the median latency period was estimated at 11 years overall, being somewhat longer for asbestos- and shorter for smoking-induced tumours. Latency periods seemed to be inversely related to the average intensities of both asbestos and smoking. In a multistage model, the best fit was obtained with asbestos acting at the fourth and smoking at the fifth stages. Lifetime risks of lung cancer are projected. Annex: mathematical formulation of the exposure indices. |
| Descriptors (primary) |
asbestos; smoking; statistical evaluation; length of exposure; lung cancer |
| Descriptors (secondary) |
latency; age-linked differences; prediction formulae; carcinogenic effects; mathematical models; dose-response relationship |
| Document type |
D - Periodical articles |
| Subject(s) |
Occupational pathology
|
| Broad subject area(s) |
|
| Browse category(ies) |
Asbestos
Statistical methods
Smoking
Diseases of the respiratory system (except for pneumoconiosis & similar)
|
