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Document ID (ISN)41924
CIS number 84-991
ISBN(s) 951-801-352-7
Year 1983
Convention or series no.
Author(s) Linnainmaa K.
Title Genotoxicity of phenoxy acid herbicides 2,4-D and MCPA
Bibliographic information Institute of Occupational Health, University of Helsinki, Haartmaninkatu 1, Helsinki, Finland, 1983. 140p. Illus. Bibl.
Abstract Academic dissertation. There was no correlation between exposure of sprayers to 2,4-D or MCPA and the frequency of sister chromatid exchanges (SCE) in their blood lymphocytes. Exposure of rats to the compounds likewise gave no increase in lymphocyte SCE. MCPA gave a slight increase in SCE in the bone marrow of Chinese hamsters; 2,4-D and the drug clofibrate (a suspected carcinogen structurally related to 2,4-D and MCPA) did not. Both herbicides gave a slight increase in SCE in hamster ovary cells in culture, but there was no dose-effect correlation and no relation between the frequency of SCE and the purity of the compounds administered. Both 2,4-D and MCPA induced proliferation of peroxysomes in the livers of hamsters and rats, and decreased serum lipid levels in rats; both effects are typical of clofibrate. Thus, any genotoxic effect that the herbicides might have would be due to the same indirect mechanism as that postulated for clofibrate.
Descriptors (primary) herbicides; phenoxyacetic acids; chromosome changes; crop protection; toxicology
Descriptors (secondary) chloromethylphenoxyacetic acid; Finland; animal experiments; thesis; dichlorophenoxyacetic acid
Document type E - Books, reports, proceedings
Subject(s) Toxic and dangerous substances
Broad subject area(s)
Browse category(ies) Agricultural chemicals
Genetic factors in reaction to exposures
Antifertility and prenatal effects