| Document ID (ISN) | 41924 |
| CIS number |
84-991 |
| ISBN(s) |
951-801-352-7 |
| Year |
1983 |
| Convention or series no. |
|
| Author(s) |
Linnainmaa K. |
| Title |
Genotoxicity of phenoxy acid herbicides 2,4-D and MCPA |
| Bibliographic information |
Institute of Occupational Health, University of Helsinki, Haartmaninkatu 1, Helsinki, Finland, 1983. 140p. Illus. Bibl. |
| Abstract |
Academic dissertation. There was no correlation between exposure of sprayers to 2,4-D or MCPA and the frequency of sister chromatid exchanges (SCE) in their blood lymphocytes. Exposure of rats to the compounds likewise gave no increase in lymphocyte SCE. MCPA gave a slight increase in SCE in the bone marrow of Chinese hamsters; 2,4-D and the drug clofibrate (a suspected carcinogen structurally related to 2,4-D and MCPA) did not. Both herbicides gave a slight increase in SCE in hamster ovary cells in culture, but there was no dose-effect correlation and no relation between the frequency of SCE and the purity of the compounds administered. Both 2,4-D and MCPA induced proliferation of peroxysomes in the livers of hamsters and rats, and decreased serum lipid levels in rats; both effects are typical of clofibrate. Thus, any genotoxic effect that the herbicides might have would be due to the same indirect mechanism as that postulated for clofibrate. |
| Descriptors (primary) |
herbicides; phenoxyacetic acids; chromosome changes; crop protection; toxicology |
| Descriptors (secondary) |
chloromethylphenoxyacetic acid; Finland; animal experiments; thesis; dichlorophenoxyacetic acid |
| Document type |
E - Books, reports, proceedings |
| Subject(s) |
Toxic and dangerous substances
|
| Broad subject area(s) |
|
| Browse category(ies) |
Agricultural chemicals
Genetic factors in reaction to exposures
Antifertility and prenatal effects
|
