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CISDOC database

Document ID (ISN)41899
CIS number 84-838
ISSN - Serial title 0025-729X - Medical Journal of Australia
Year 1983
Convention or series no.
Author(s) Pearn J.H.
Title Teratogens and the male - An analysis with special reference to herbicide exposure
Bibliographic information 9 July 1983, Vol.2, No.1, p.16-20. 44 ref.
Abstract There are 3 mechanisms by which exposure of the male to toxic substances may cause poor reproductive performance or congenital malformations in his offspring: a direct effect on pituitary-hypothalamic function or male sex hormones; a direct effect on the sperm itself; abnormalities in seminal fluid with secondary abnormalities due to dissolved toxins. Experimental studies with 7 drugs and 5 groups of toxic chemicals are reviewed. Clinical studies reviewed relate to lead, vinyl chloride, the insecticide carbaryl, the pesticides chlordecone and dibromochloropropane, radiation, fathers with epilepsy, and male and female anaesthetists.
Descriptors (primary) herbicides; sex-linked differences; genetic effects; teratogens
Descriptors (secondary) ionizing radiation; round-up; polychlorinated biphenyls; kepone; lead; dichlorophenoxyacetic acid; trichlorophenoxyacetic acid; tetrachlorodibenzodioxin; inhalation anaesthetics; epilepsy; pesticides; insecticides; Nemagon; carbaryl; thalidomide; vinyl chloride
Document type D - Periodical articles
Subject(s) Occupational pathology
Broad subject area(s)
Browse category(ies) Agricultural chemicals
Genetic factors in reaction to exposures
Antifertility and prenatal effects