ILO Home
Go to the home page
Site map | Contact us Franšais | Espa˝ol

CISDOC database

Document ID (ISN)41877
CIS number 84-736
ISSN - Serial title Gigiena truda i professional'nye zabolevanija
Year 1982
Convention or series no.
Author(s) Kuz'minov B.P.
Title Bases for an MAC for polidazol in workplace air
Original title Obosnovanie PDK polidazola v vozduhe rabočej zony [in Russian]
Bibliographic information Sep. 1982, No.9, p.54. 3 ref.
Abstract The fungicide polidazol was subjected to a standard battery of toxicological tests with rats, mice and guinea pigs. The toxicity of the compound was species-dependent (LD50s for the 3 species were 2432, 6760 and 700mg/kg, respectively), but by any measure the compound falls into the category of moderately toxic substances; the LC50 of airborne polidazol dust could not be determined, as the highest attainable dust concentrations were not lethal. The compound was neurotoxic and gonadotoxic, and produced dystrophic changes in the liver, kidneys and lungs of experimental animals. As the gonadotoxic action of the compound was observed on chronic exposure to as little as 1mg/m3, an MAC of 0.1mg/m3 is recommended for polidazol factories.
Descriptors (primary) threshold limit values; USSR; pesticide production; fungicides; polidazol; toxicology
Descriptors (secondary) neurotoxic effects; hepatotoxic effects; pneumotoxic effects; gonadotropic effects; nephrotoxic effects; animal experiments
Document type D - Periodical articles
Subject(s) Toxic and dangerous substances
Broad subject area(s)
Browse category(ies) Agricultural chemicals
Genetic factors in reaction to exposures
Occupational exposure limits
Chemical industry