|Document ID (ISN)||41877|
|ISSN - Serial title
||Gigiena truda i professional'nye zabolevanija
|Convention or series no.
||Bases for an MAC for polidazol in workplace air
||Obosnovanie PDK polidazola v vozduhe rabočej zony [in Russian]|
||Sep. 1982, No.9, p.54. 3 ref.
||The fungicide polidazol was subjected to a standard battery of toxicological tests with rats, mice and guinea pigs. The toxicity of the compound was species-dependent (LD50s for the 3 species were 2432, 6760 and 700mg/kg, respectively), but by any measure the compound falls into the category of moderately toxic substances; the LC50 of airborne polidazol dust could not be determined, as the highest attainable dust concentrations were not lethal. The compound was neurotoxic and gonadotoxic, and produced dystrophic changes in the liver, kidneys and lungs of experimental animals. As the gonadotoxic action of the compound was observed on chronic exposure to as little as 1mg/m3, an MAC of 0.1mg/m3 is recommended for polidazol factories.
||threshold limit values; USSR; pesticide production; fungicides; polidazol; toxicology
||neurotoxic effects; hepatotoxic effects; pneumotoxic effects; gonadotropic effects; nephrotoxic effects; animal experiments
||D - Periodical articles
||Toxic and dangerous substances
|Broad subject area(s)
Genetic factors in reaction to exposures
Occupational exposure limits