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Document ID (ISN)41842
CIS number 84-816
Year 1981
Convention or series no.
Author(s) Norppa H.
Title Chromosome damage induced by styrene, styrene oxide and some analogues
Bibliographic information Institute of Occupational Health, University of Helsinki, Haartmaninkatu 1, Helsinki, Finland, 1981. 56p. Illus. 111 ref.
Abstract Academic dissertation, including a review of the literature on the metabolism and genotoxicity of styrene. In vitro (cultures of human peripheral lymphocytes), styrene and styrene 7,8-oxide, the main reactive metabolite of styrene, and some of their analogues produced structural chromosome aberrations and sister chromatid exchanges. Although styrene oxide was apparently mutagenic in human lymphocytes, neither styrene nor styrene oxide produced detectable chromosome damage in the bone marrow of hamsters. Styrene and vinyltoluene did cause chromosome breakage in the bone marrow of mice, as indicated by the micronucleus induction test. The difference between the 2 rodents is probably due to the relatively low activity of epoxide hydrolase in the mouse, which makes the mouse less able to inactivate styrene oxide.
Descriptors (primary) mutagens; styrene; cytotoxic effects; chromosome changes; styrene oxide
Descriptors (secondary) literature survey; lymphocytes; Finland; metabolic process; in vitro experiments; vinyltoluene; smoking; thesis; methylstyrenes
Document type E - Books, reports, proceedings
Subject(s) Occupational pathology
Broad subject area(s)
Browse category(ies) Antifertility and prenatal effects
Genetic factors in reaction to exposures
Aromatic hydrocarbons
Ethers
Ethylene oxide