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CISDOC database
| Document ID (ISN) | 41842 |
| CIS number |
84-816 |
| Year |
1981 |
| Convention or series no. |
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| Author(s) |
Norppa H. |
| Title |
Chromosome damage induced by styrene, styrene oxide and some analogues |
| Bibliographic information |
Institute of Occupational Health, University of Helsinki, Haartmaninkatu 1, Helsinki, Finland, 1981. 56p. Illus. 111 ref. |
| Abstract |
Academic dissertation, including a review of the literature on the metabolism and genotoxicity of styrene. In vitro (cultures of human peripheral lymphocytes), styrene and styrene 7,8-oxide, the main reactive metabolite of styrene, and some of their analogues produced structural chromosome aberrations and sister chromatid exchanges. Although styrene oxide was apparently mutagenic in human lymphocytes, neither styrene nor styrene oxide produced detectable chromosome damage in the bone marrow of hamsters. Styrene and vinyltoluene did cause chromosome breakage in the bone marrow of mice, as indicated by the micronucleus induction test. The difference between the 2 rodents is probably due to the relatively low activity of epoxide hydrolase in the mouse, which makes the mouse less able to inactivate styrene oxide. |
| Descriptors (primary) |
mutagens; styrene; cytotoxic effects; chromosome changes; styrene oxide |
| Descriptors (secondary) |
literature survey; lymphocytes; Finland; metabolic process; in vitro experiments; vinyltoluene; smoking; thesis; methylstyrenes |
| Document type |
E - Books, reports, proceedings |
| Subject(s) |
Occupational pathology
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| Broad subject area(s) |
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| Browse category(ies) |
Ethylene oxide
Ethers
Genetic factors in reaction to exposures
Antifertility and prenatal effects
Aromatic hydrocarbons
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