ILO Home
Go to the home page
Site map | Contact us Français | Español

CISDOC database

Document ID (ISN)41772
CIS number 84-789
ISSN - Serial title 0096-1736 - Journal of Occupational Medicine
Year 1983
Convention or series no.
Author(s) Gibson E.S., McCalla D.R., Kaiser-Farrell C., Kerr A.A., Lockington J.N., Hertzman C., Rosenfeld J.M.
Title Lung cancer in a steel foundry: a search for causation
Bibliographic information Aug. 1983, Vol.25, No.8, p.573-578. Illus. 21 ref.
Abstract An Ames assay of particulate mutagenicity was taken at the pouring floor, core room, bench moulding, chip shop and electric furnace areas of a foundry and in the outside air. Mutagenic activity was found in all foundry areas and was substantially higher than in the outside samples. There was considerable variation within sites, but overall activity was highest in the crane area above the pouring floor, intermediate in the moulding area, and lowest in the electric furnace samples. There was a relatively large direct-acting mutagenic component indicating the presence of compounds other than polycyclic aromatic hydrocarbon (PAH) carcinogens, associated with material >7µm in diameter. PAH carcinogen levels may represent only a fraction of total mutagenicity.
Descriptors (primary) mutagens; carcinogens; foundries; iron and steel industry; lung cancer
Descriptors (secondary) aromatic hydrocarbons; mutagenicity tests; polycyclic hydrocarbons
Document type D - Periodical articles
Subject(s) Occupational pathology
Broad subject area(s)
Browse category(ies) Diseases of the respiratory system (except for pneumoconiosis & similar)
Foundries, metalcasting and forging operations
Iron and steel industry