| Document ID (ISN) | 41754 |
| CIS number |
84-788 |
| ISSN - Serial title |
0705-9388 - Occupational Health in Ontario |
| Year |
1984 |
| Convention or series no. |
|
| Author(s) |
Waterman F.K. |
| Title |
Equilibrium of CO between the pregnant mother and the foetus |
| Bibliographic information |
Jan. 1984, Vol.5, No.1, p.10-22. Illus. 39 ref. |
| Abstract |
Carboxyhaemoglobin (COHb) levels in foetal blood after maternal exposure to carbon monoxide (CO) are investigated. Because of poor solubility of CO in plasma and because of resistance by the placental membranes, the half-time of CO diffusion across the placenta is approx. 2h. The Ontario TLV for CO is 35ppm (time-weighted average exposure), at which exposure level maternal COHb concentration is 5.3%, with foetal COHb concentration rising to 15% above maternal levels after 36-48h of steady-state exposure. At higher levels of exposure (e.g. 100ppm for 4h), greater than expected incidence of foetal neurological damage, lower birthweight, spontaneous abortions, stillbirths and later learning problems has been reported. No margin of safety should be assumed for the foetus even at maternal exposures at or below the TLV level. |
| Descriptors (primary) |
embryotoxic effects; expectant mothers; carboxyhaemoglobin level; carbon monoxide |
| Descriptors (secondary) |
neurotoxic effects; abortion; Ontario |
| Document type |
D - Periodical articles |
| Subject(s) |
Occupational pathology
|
| Broad subject area(s) |
|
| Browse category(ies) |
Inorganic substances
Blood diseases
Carbon monoxide
|
