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CISDOC database

Document ID (ISN)41710
CIS number 84-768
ISSN - Serial title Proceedings of the Osaka Prefectural Institute of Public Health
Year 1982
Convention or series no.
Author(s) Suenaka T.
Title Urinary excretion of heavy metals (Pb, Fe, Zn, Cu) following injection of Ca-EDTA
Bibliographic information Edition of Industrial Health, Sep. 1982, Vol.20, p.23-26. Illus. 5 ref.
Abstract Oral administration and infusion of calcium-EDTA were compared, as means of therapy in workers exposed to lead (Pb), by monitoring urinary excretion of Pb, iron, copper, and zinc (Zn), after administration. Urinary excretion of these metals in toto was 10 times greater after infusion than after oral administration. Comparison of daily infusion for 3-8 days and infusion 6 times with 2 week intervals revealed no significant difference in total urinary excretion of the metals. As the excretion of Pb decreased, that of Zn increased. The method of administration and intervals used in Ca-EDTA therapy should be considered in the light of these findings.
Descriptors (primary) iron; copper; chelation therapy; lead; urinary excretion; zinc
Descriptors (secondary) EDTA; urine monitoring; injections; ingestion
Document type D - Periodical articles
Subject(s) Occupational pathology
Broad subject area(s)
Browse category(ies) Inorganic substances
Lead and compounds
Iron and compounds
Copper and compounds