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Document ID (ISN)41636
CIS number 84-697
ISSN - Serial title 0016-9900 - Gigiena i sanitarija
Year 1982
Convention or series no.
Author(s) Alehina S.M., Kuz'minskaja U.A.
Title State of adaptive processes under different regimes of kelthane administration
Original title Sostojanie adaptacionnyh processov pri različnyh režimah vvedenija kel'tana [in Russian]
Bibliographic information Aug. 1982, No.8, p.20-22. Illus. 8 ref.
Abstract The pesticide kelthane (related to DDT) was administered perorally to rats at 1/100 of the LD50 at intervals of a day ("continuously") or a week ("intermittently"), and the metabolic adaptation of the animals was determined by measurement of their hepatic and cardiac lactate dehydrogenase (LDH). Changes in total LDH activity, isoenzyme spectrum and substrate/product (pyruvate/lactate) equilibrium were more marked in the case of continuous administrtion than under intermittent administration. This dependence of response on pattern of exposure should be taken into account in the formulation of regulations for the handling of pesticides.
Descriptors (primary) pesticides; determination of exposure limits; kelthane; toxicology
Descriptors (secondary) conditions of exposure; animal experiments; enzyme disturbances
Document type D - Periodical articles
Subject(s) Toxic and dangerous substances
Broad subject area(s)
Browse category(ies) Alcohols
Agricultural chemicals