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Document ID (ISN)41612
CIS number 84-748
ISSN - Serial title 0098-4108 - Journal of Toxicology and Environmental Health
Year 1983
Convention or series no.
Author(s) Allen A.L., Koller L.D., Pollock G.A.
Title Effect of toxaphene exposure on immune responses in mice
Bibliographic information Jan. 1983, Vol.11, No.1, p.61-69. 34 ref.
Abstract 10, 100 or 200ppm toxaphene was given orally to mice for 8 weeks. Antibody formation was depressed in animals receiving 100 and 200ppm. Cell-mediated immune responses were not affected. Offspring of female mice receiving 100 and 200ppm toxaphene for 3 weeks before mating and during gestation and lactation showed suppression and enhancement of antibody formation, respectively. Cell-mediated immune response was suppressed in the offspring of those receiving 100ppm. All mice receiving toxaphene showed a significant reduction of phagocytic ability of macrophages.
Descriptors (primary) toxaphene; serological reactions; immunobiological changes; insecticides
Descriptors (secondary) macrophages; ingestion; comparative study; histopathology; animal experiments
Document type D - Periodical articles
Subject(s) Occupational pathology
Broad subject area(s)
Browse category(ies) Halogenated hydrocarbons
Agricultural chemicals