ILO Home
Go to the home page
Site map | Contact us Franšais | Espa˝ol

CISDOC database

Document ID (ISN)41514
CIS number 84-509
ISSN - Serial title 0019-8366 - Industrial Health
Year 1982
Convention or series no.
Author(s) Saegusa J., Hasegawa H., Kawai K.
Title Toxicity of 1,2-dibromo-3-chloropropane (DBCP) - I. Histopathological examination of male rats exposed to DBCP vapour
Bibliographic information 1982, Vol.20, No.4, p.315-323. Illus. 17 ref.
Abstract Male rats were exposed to 1,2-dibromo-3-chloropropane (DBCP) at 10ppm for 14 days and were sacrified 1, 16 amd 36 days, and 12 months after exposure. Examination revealed that the testicles had completely atrophied with irreversible aspermatogenesis. Renal injury was characterised by proximal tubular necrosis in the outer medulla. In the lung, necrosis and cytomegaly were observed in the bronchial and bronchiolar epithelial cells as well as alveolar emphysema. Examination of the testicles 1 and 15 days after exposure for 14 days to 0, 0.3, 1, 3 and 8ppm DBCP revealed pathological changes in the 3 and 8ppm exposure groups only with recovery and a progressive course, respectively.
Descriptors (primary) nematocides; biological effects; Nemagon; toxicology
Descriptors (secondary) renal damage; testicular atrophy; inhalation toxicity; animal experiments; lung diseases
Document type D - Periodical articles
Subject(s) Occupational pathology
Broad subject area(s)
Browse category(ies) Halogenated hydrocarbons
Agricultural chemicals