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CISDOC database
| Document ID (ISN) | 41510 |
| CIS number |
84-505 |
| ISBN(s) |
0-11-883681-1 |
| Year |
1983 |
| Convention or series no. |
Toxicity Review TR 7
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| Author(s) |
Fielder R.J., Dale E.A., Sorrie G.S., Bishop C.M., Van Den Heuvel M.J., Pryde E., Fletcher A.P. |
| Title |
Cadmium and its compounds |
| Bibliographic information |
Health and safety Executive, Baynards House, 1 Chepstow Place, London W2 4TF, United Kingdom, 1983. 88p. 323 ref. |
| Abstract |
Subjects discussed are metabolism, toxicity to animals, toxicity to man. Metabolism of Cd in man is similar to that of rodents and other mammals. Cd compounds are poorly absorbed orally but are well absorbed through the lungs. Cd is very efficiently retained in the body, and only very small amounts are excreted, the retained material being deposited mainly in the liver and kidneys. Excretion is mainly via the urine, in very small quantities which increase with duration of exposure and reflect the renal Cd concentration and thus total body burden unless kidney dysfunction is present, when urinary Cd increases markedly. Studies of exposed workers in the United Kingdom, USA, Japan, Sweden, and Belgium are reviewed. The results of numerous animal experiments from the literature are tabulated. |
| Descriptors (primary) |
cadmium and compounds; harmful substances; toxicology; United Kingdom |
| Descriptors (secondary) |
mutagenic effects; kidney; liver; metabolic process; renal dysfunction; lethal dose 50; genetic effects; chromosome changes; carcinogenic effects; inhalation toxicity; cadmium; respiratory impairment; data sheet; determination in urine; antifertility effects |
| Document type |
F - Information notes, codes of practice, standards |
| Subject(s) |
Occupational pathology
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| Broad subject area(s) |
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| Browse category(ies) |
Inorganic substances
Genetic factors in reaction to exposures
Cadmium and compounds
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