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Document ID (ISN)41469
CIS number 84-488
ISSN - Serial title 0098-4108 - Journal of Toxicology and Environmental Health
Year 1982
Convention or series no.
Author(s) Kluwe W.M., Haseman J.K., Douglas J.F., Huff J.E.
Title The carcinogenicity of dietary di(2-ethylhexyl) phthalate (DEHP) in Fischer 344 rats and B6C3F1 mice
Bibliographic information Oct.-Nov. 1982, Vol.10, Nos.4-5, p.797-815. Illus. 43 ref.
Abstract Groups of 50 male and female rats and male and female mice were fed diets containing 6000 or 12000 (rats) or 3000 or 6000 (mice) mg di(2-ethylhexyl) phthalate (DEHP)/kg for 103 consecutive weeks. Treatment with DEHP did not affect survival rates for rats or mice, compared with controls, nor did it alter the amount of food consumed. Mean body weight gains of the treated animals were less than those of controls. Treatment with DEHP caused liver tumours in both sexes of mice and rats. The combined incidence of animals with hepatocellular carcinomas or neoplastic nodules was significantly greater than that in controls for male rats ingesting 12000mg/kg and female rats ingesting 6000mg/kg. The combined incidence of animals with hepatocellular carcinomas or adenomas was significantly greater than that in controls for male mice ingesting 3000mg/kg. 20 of the 57 hepatocellular carcinomas diagnosed in DEHP-treated mice had metastasised to the lung.
Descriptors (primary) carcinogens; plasticizers; toxicology; bis(ethylhexyl) phthalate
Descriptors (secondary) animal experiments; plastics industry; carcinogenic effects
Document type D - Periodical articles
Subject(s) Occupational pathology
Broad subject area(s)
Browse category(ies) Phthalates
Esters and salts