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Document ID (ISN)41467
CIS number 84-487
ISSN - Serial title 0098-4108 - Journal of Toxicology and Environmental Health
Year 1982
Convention or series no.
Author(s) Cushman J.R., Street J.C.
Title Allergic hypersensitivity to the herbicide 2,4-D in BALB/c mice
Bibliographic information Oct.-Nov. 1982, Vol.10, Nos.4-5, p.729-741. Illus. 35 ref.
Abstract Following several reports of human allergic hypersensitivity, the ability of 2,4-dichlorophenoxyacetic acid (2,4-D) to elicit 2,4-D-specific IgE antibodies and delayed-type hypersensitivity in mice was studied. Following the second intraperitoneal immunisation with 1, 10 or 100µg of a 2,4-D conjugate, 2,4-D-specific IgE antibodies were detected in mouse sera. The highest antibody titers and a measurable response in all mice were seen in the group that received 1µg of 2,4-D conjugate. 2,4-D applied epicutaneously on 2 days or over 4 weeks failed to elicit delayed-type hypersensitivity, and no 2,4-D-specific IgE antibodies were detected in serum.
Descriptors (primary) herbicides; immunology; allergies; dichlorophenoxyacetic acid
Descriptors (secondary) immunoglobulin changes; animal experiments; crop protection
Document type D - Periodical articles
Subject(s) Occupational pathology
Broad subject area(s)
Browse category(ies) Allergies
Agricultural chemicals