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CISDOC database

Document ID (ISN)41338
CIS number 84-457
ISSN - Serial title 0355-3140 - Scandinavian Journal of Work, Environment and Health
Year 1982
Convention or series no.
Author(s) Perocco P., Pane G., Bolognesi S., Zannotti M.
Title Increase of sister chromatid exchange and unscheduled synthesis of desoxyribonucleic acid by acrylonitrile in human lymphocytes in vitro
Bibliographic information Dec. 1982, Vol.8, No.4, p.290-293. Illus. 17 ref.
Abstract Acrylonitrile was toxic starting from a concentration of 5 x 10-3M, caused a small but significant increase in sister chromatid exchanges compared with controls at 5 x 10-4M with metabolic activation, and elicited reparative (unscheduled) DNA synthesis as determined by tritiated thymidine uptake, particularly at a concentration of 5 x 10-1M. The toxic and mutagenic actions of acrylonitrile were observable only at very high concentrations, which are not comparable with those occurring at the workplace. Given the massive production and use of acrylonitrile, genotoxic effects could be produced in man by prolonged continuous exposure.
Descriptors (primary) mutagenic effects; chromosome changes; acrylonitrile; DNA
Descriptors (secondary) in vitro experiments; lymphocytes
Document type D - Periodical articles
Subject(s) Occupational pathology
Broad subject area(s)
Browse category(ies) Antifertility and prenatal effects
Cyano compounds
Genetic factors in reaction to exposures