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Document ID (ISN)41020
CIS number 84-147
ISSN - Serial title 0002-8894 - American Industrial Hygiene Association Journal
Year 1983
Convention or series no.
Author(s) Hackathorn D.R., Brinkman W.J., Hathaway T.R., Talbott T.D., Thompson L.R.
Title Validation of a whole blood method for cholinesterase monitoring
Bibliographic information July 1983, Vol.44, No.7, p.547-551 24 ref.
Abstract Traditional methods for monitoring worker exposure to organophosphate and carbamate insecticides, requiring several cm3 of blood, are too invasive for prolonged routine monitoring. The new method requires only 50Ál of blood per test. Its sensitivity and reproducibility, evaluated over 1 year and 7073 tests, are excellent. The coefficient of variation for 12 groups tested ranged from 9.4 to 13% with a value of 10% for the control group. Assessment of the significance of cholinesterase by the whole-blood method is similar to the erythrocyte cholinesterase method and should use the following criteria: (1) baseline value is established by 3 separate tests prior to exposure; (2) investigate and correct possible exposure situations for readings at 70% of baseline value; (3) remove employee from exposure when readings are 60% of baseline value.
Descriptors (primary) cholinesterase monitoring; exposure tests; determination in blood; pesticides
Descriptors (secondary) carbamates; organophosphorus compounds
Document type D - Periodical articles
Subject(s) Occupational pathology
Broad subject area(s)
Browse category(ies) Biological monitoring
Agricultural chemicals