|Document ID (ISN)||40589|
|Convention or series no.
||Genotoxic hazards in the rubber industry
||Genotoxiska risker i gummiindustrin [in Swedish]|
||Arbetarskyddsfonden, Box 1122, 11181 Stockholm, Sweden, 1982. 202p. Illus. 25 ref.
||Final report of a major study of the genotoxic and teratogenic hazards of exposure to rubber chemicals. The 80 chemicals whose effects were examined belonged to these groups: vulcanisers, vulcanisation accelerators, antioxidants, retarding agents, vulcanisation gases. To measure genotoxicity, the Ames test for mutagens in Salmonella was used, and strong mutagenic effects were found with thiurams, dithiocarbamates (both vulcanisation accelerators) and with almost all the vulcanisation gases. Other genotoxic tests confirmed the results of the Ames test. For embryotoxic and teratogenic effects, the chemicals were tested with chicken embryos, and the effective dose 50 (ED50) level was tabulated, together with the maximum percentage of malformed embryos. Urinary mutagenicity in rubber workers was measured and correlated with type of work and smoking. The biochemistry of the genotoxic process after exposure to thiurams and dithiocarbamates is described. Cancer and miscarriage epidemiology in rubber workers are discussed. Protective measures in the rubber industry are suggested.
||mutagens; genetic effects; teratogens; rubber industry
||embryotoxic effects; tetramethylthiuram monosulfide; vulcanization accelerators; disulfiram; tetramethylthiuram disulfide; dithiocarbamates; smoking; vulcanizers; abortion; epidemiologic study; in vitro experiments; mutagenicity tests; carcinogenic effects; determination in urine; antioxidants; vulcanizing agents; effective dose 50
||E - Books, reports, proceedings
||Chemicals, plastics and rubber
|Broad subject area(s)
||Antifertility and prenatal effects
Genetic factors in reaction to exposures