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CISDOC database

Document ID (ISN)40291
CIS number 83-1398
ISSN - Serial title 0095-6562 - Aviation, Space, and Environmental Medicine
Year 1982
Convention or series no.
Author(s) Schatte C.L., Mathias M.M.
Title Effect of dietary fat on pulmonary enzymes and toxicity during normobaric hyperoxia
Bibliographic information July 1982, Vol.53, No.7, p.629-632. 25 ref.
Abstract Male rats were fed a diet containing 10, 20, 40 or 60% of calories as fat having a constant polyunsaturated/saturated fatty acid ratio of 0.7. After 21-28 days of feeding, the animals were exposed to pure oxygen at 1atm for ≤72 hours. Some animals were sacrificed after 0 or 48h of oxygen exposure, and lung tissue was analysed for the activities of the hexose-monophosphate shunt and prostaglandin dehydrogenase/reductase. Other animals were exposed to hyperoxia until death. With increasing dietary fat content, the pre-exposure activities of the 2 enzymes decreased and oxygen-induced mortality increased. There was no dietary effect on enzyme activities after 48h of hyperoxia.
Descriptors (primary) toxic effects; oxygen; diet
Descriptors (secondary) animal fats and oils; vegetable oils and fats; hyperoxia; enzyme disturbances; animal experiments; enzyme activity
Document type D - Periodical articles
Subject(s) Occupational pathology
Broad subject area(s)
Browse category(ies) Inorganic substances
Nutrition